MONOCULUS
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vs.
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Scout
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 Playing as Scout allows you to evade MONOCULUS' attacks more easily than other classes due to your agility and ability to double and triple jump.
Hit-and-run tactics are a necessity when attacking MONOCULUS.
The Scout's agility, double and triple jumps allow him to enter into and survive the underworld with more ease than other classes.
 Bonk! Atomic Punch will allow you to survive MONOCULUS' eyeball projectiles for a short time, and can use knock back to escape.
Because base damage is retained at all ranges when attacking MONOCULUS, the Scattergun will deal the most damage to it, provided you can move to around medium range to ensure you don't partially miss your shots.
The Pistol can be effective against MONOCULUS, as base damage remains the same when attacking it. This will allow you to do more damage from a longer range than normal.
The Shortstop allows you to deal a good amount of damage at medium-range because of its 100% increase in damage per pellet.
 Do not use Crit-a-Cola against MONOCULUS. Your attacks will deal no extra damage and will make it easier for MONOCULUS to kill you.
The Sandman baseball and Fan O'War are ineffective against MONOCULUS, as it cannot be stunned by baseballs or marked for death.
The Scout's health is low enough that a single hit from MONOCULUS' projectiles will likely result in death.
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MONOCULUS
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vs.
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Soldier
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Rocket jumping is a viable method of evading MONOCULUS' projectiles.
The Buff Banner, Battalion's Backup, and Concheror will charge on dealing damage to MONOCULUS.
A Kritzkrieg ÜberCharge will allow a skilled Soldier to make short work of MONOCULUS, as a pack of critical rockets and Shotgun shells will take a large chunk of its health away.
The Direct Hit is probably the Soldier's best primary weapon to use against MONOCULUS. The projectiles are fast and do high damage, and MONOCULUS is large enough for you not to worry too much about missing it.
The Shotgun can be effective against MONOCULUS, as base damage remains the same when attacking it. This will allow you to do more damage from a longer range than normal.
Charging MONOCULUS with the Equalizer at very low health will only be effective if the enemy team is not around and MONOCULUS is stunned, as your crits will deal around 300 damage. Otherwise, it's a risky strategy.
The Buff Banner will charge when doing damage to MONOCULUS, but MONOCULUS is not affected by mini-crits, so using it is not recommended.
The Reserve Shooter will not mini-crit against MONOCULUS and is not recommended.
The Black Box does not award health upon hitting MONOCULUS and is a considerable drawback when its reduced ammo is taken into account.
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MONOCULUS
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vs.
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Pyro
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Because MONOCULUS does not suffer afterburn damage, using the Pyro against MONOCULUS is inadvisable. In addition, the Pyro's short range of effectiveness and MONOCULUS' resistance to Flamethrowers makes attacking head-on a very deadly prospect.
A skilled Pyro may be able to effectively attack MONOCULUS by using air blasts to reflect MONOCULUS's projectiles back at it. However, unless MONOCULUS is angry, these projectiles will travel slowly and will often miss their target.
The Backburner can be moderately effective if MONOCULUS is distracted.
The Shotgun can be effective against MONOCULUS, as base damage remains the same when attacking it. This will allow you to do more damage from a longer range than normal.
The Reserve Shooter will not mini-crit against MONOCULUS and is not recommended.
The Flare Gun, the Detonator, and the Scorch Shot are possibly some of the worst weapons to use against MONOCULUS, as he cannot catch on fire. Only the minimal flare impact damage will register.
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MONOCULUS
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vs.
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Demoman
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It is possible to briefly dodge MONOCULUS' projectiles by charging with the Chargin' Targe or Splendid Screen in a single direction across open ground.
Direct hits with the Grenade Launcher or Loch-n-Load will cause large amounts of damage to MONOCULUS, so it is advisable to lead your shots slightly to ensure they connect. This strategy is especially effective with a Kritzkrieg ÜberCharge.
Stickybombs are almost rendered completely ineffective against MONOCULUS, as it is generally flying too high or teleporting too quickly to set up a trap. However, a skilled Demoman may be able to arc his shot so it can be detonated to do max damage.
Attempting the above strategy with the Scottish Resistance is extremely difficult due to the slower arming time of the bombs.
Demoknights are not recommended, as they cannot effectively reach MONOCULUS unless it has been stunned or is near the ground.
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MONOCULUS
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vs.
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Heavy
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The Heavy is one of the best classes to go head-on against MONOCULUS. Despite its resistance to Minigun bullets, any Minigun will shred the boss in a matter of seconds at short range, even without crits.
Be aware that the Heavy has no real means of effectively dodging MONOCULUS' projectiles, but can withstand at least one direct hit from one. A Heavy can rely on the Gloves of Running Urgently to escape in such situations.
A Heavy/Medic pair can camp the control point while building up a Kritzkrieg ÜberCharge. The damage resulting from such an attack is usually enough to deal extremely high levels of damage to MONOCULUS. Be ready to escape though, as MONOCULUS will not only be angered, but it will make you both its primary target.
The Fists of Steel have some usability as a temporary distraction, since it halves the damage done by MONOCULUS' projectiles.
The Buffalo Steak Sandvich is not recommended, since the speed bonus is countermanded by the duration of eating and increased damage vulnerability.
The Shotgun should rarely be used, as the time between shots and damage spread mean you will always get more damage from your primary weapon. Nonetheless, if you have run out of ammunition for your primary weapon, remember that base damage remains constant while attacking MONOCULUS, so you can use the Shotgun effectively from further ranges than normal.
The Brass Beast, even with a Kritzkrieg ÜberCharge, is only recommended if MONOCULUS is already busy, as your extremely sluggish movement will tempt even the enemy team to focus on you and make you an easy target for an angry MONOCULUS' projectiles.
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MONOCULUS
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vs.
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Engineer
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Since MONOCULUS is not affected by knockback, the player should never rely on his Sentry to keep the monster away.
MONOCULUS will attack anything within his range - this includes players and buildings. Keep in mind that wrangled Sentry Guns can survive a few projectile hits, allowing you and your team to profit from the distraction. Don't rely on them too much, though; it only takes one or two rounds of MONOCULUS' projectiles to destroy an entire sentry nest.
Sentry Guns will target MONOCULUS even when it is outside their normal range.
Because Sentry Guns never deal critical hits, your Sentry Gun can be an effective way to deal damage to MONOCULUS without angering it. Use the Wrangler for maximum damage.
The Shotgun and Pistol can both be effective against MONOCULUS, as their base damage remains the same when attacking it. This will allow you to do more damage from a longer range than normal.
The Short Circuit is able to protect the Engineer by destroying MONOCULUS's projectiles.
The Widowmaker does not return metal for damage done to MONOCULUS.
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MONOCULUS
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vs.
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Medic
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Use your ÜberCharge on a teammate so they can attack MONOCULUS. While MONOCULUS will ignore invulnerable individuals for as long as possible, keep in mind that it will attempt to target you if you are in range.
If you do not have an ÜberCharge ready, it is best advised to stay away and build one up.
If using a Kritzkrieg ÜberCharge to attack MONOCULUS, be ready for a quick escape, as MONOCULUS will not only be angered, but it will make you and your buddy its primary targets.
Most of the Medic's weapons are relatively ineffective, so the Medic should be reserved to a support role.
The Crusader's Crossbow can be useful for quick heals, since it is largely ineffective against MONOCULUS at close range. It can also be marginally useful if you have good long distance aim to shoot MONOCULUS.
Kritzkrieg charges are normally risky against MONOCULUS, but combining it with a standard ÜberCharge on a strong class like a Heavy can result in very high levels of damage. The Kritzkrieg Medic should be careful, however, since they are vulnerable to damage from an angry MONOCULUS projectile, which can easily break this strategy.
It is not very helpful to use the Quick-Fix against MONOCULUS. Its enhanced healing power will not be enough to survive MONOCULUS' deadly eyeball projectiles.
An ÜberCharged pair can be rendered largely ineffective by a wandering ghost.
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MONOCULUS
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vs.
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Sniper
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The basic Sniper Rifle has medium effectiveness against MONOCULUS, as headshots do not deal extra damage. However, charging shots is still worthwhile, as the damage will properly scale against MONOCULUS. The Machina will deal slightly more damage in this regard.
The extra range that the Sniper class exhibits can allow the player to attack while far outside MONOCULUS' attack range. This, however, will make it more difficult to travel to the Underworld to acquire the Bombinomicon.
The Sydney Sleeper's faster charge rate makes it more useful than the standard Sniper Rifle, as MONOCULUS is immune to headshots.
Jarate does not affect MONOCULUS, nor will the Sydney Sleeper provide Jarate coating effects.
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MONOCULUS
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vs.
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Spy
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The Dead Ringer's feign death ability will allow you to survive one hit per use, giving the Spy more survivability against MONOCULUS.
The Revolver and the Enforcer are the most viable weapons to use, although it should only be used against MONOCULUS if it is focused on another player.
The Spy is rather ineffective against MONOCULUS, as Backstabs cannot be landed, and knives deal negligible damage otherwise.
As with many other weapons, Your Eternal Reward, Conniver's Kunai, and the Big Earner will not grant bonuses upon attacking or killing MONOCULUS and should be avoided.
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